• Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)
  • Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)
  • Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)
  • Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)
  • Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)
  • Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)

Human CD47 protein (Active Recombinant) (C-hFc&His) (STJP001073)

SKU:
STJP001073

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human CD47-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CD47 at 1 Mu g/mL (100 Mu L/well) can bind Recombinant Human SIRP alpha with a linear range of 1-6 ng/mL.
Gene Symbol: CD47
Gene ID: 961
Uniprot ID: CD47_HUMAN
Immunogen Region: Gln19-Pro139
Immunogen: Recombinant Human CD47 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln19-Pro139) of human CD47 (Accession #NP_001768.1) fused with an Fc, 6×His tag at the C-terminus.
Tissue Specificity Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
Function Adhesive protein that mediates cell-to-cell interactions. Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering. Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging. In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells.
Protein Name Leukocyte Surface Antigen Cd47
Antigenic Surface Determinant Protein Oa3
Integrin-Associated Protein
Iap
Protein Mer6
Cd Antigen Cd47
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-391160
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Leukocyte Surface Antigen Cd47 protein
Antigenic Surface Determinant Protein Oa3 protein
Integrin-Associated Protein protein
Iap protein
Protein Mer6 protein
Cd Antigen Cd47 protein
CD47 protein
MER6 protein

Information sourced from Uniprot.org

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