| Short Description : | Recombinant-Human CD3E&CD3D (Primary Amine Labeling)-C-His protein was developed in hek293 cells using the region Asp23-Glu120. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Biotinylated Recombinant Human CD3E&CD3D/CD3 epsilon&CD3 delta Protein (Primary Amine Labeling) is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp23-Glu120 (CD3E) & Phe22-Ala105 (CD3D) ) of Human CD3E&CD |
| Immunogen Region: | Asp23-Glu120 |
| Immunogen Sequence: | DGNEEMGGITQTPYKVSISG TTVILTCPQYPGSEILWQHN DKNIGGDEDDKNIGSDEDHL SLKEFSELEQSGYYVCYPRG SKPEDANFYLYLRARVCEFK IPIEELEDRVFVNCNTSITW VEGTVGTLLSDITRLDLGKR ILDPRGIYRCNGTDIYKDKE STVQVHYRMCQSCVELDPAT VA |
| Background | T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D, are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR) , TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. |
Information sourced from Uniprot.org