Human CD38 protein (Recombinant) (STJP000502)

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STJP000502
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Short Description :Recombinant-Human CD38-protein was developed from hek293. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction:Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol:CD38
Gene ID:952
Uniprot ID:CD38_HUMAN
Immunogen:Optimized DNA sequence encoding Human extracellular domain of human CD38 including a C-terminal 6His tag was expressed in HEK293 cells. NA
Immunogen Region:ECD
Tissue Specificity Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Function Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity.
Protein Name Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1
2'-Phospho-Adp-Ribosyl Cyclase
2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase
2'-Phospho-Cyclic-Adp-Ribose Transferase
Adp-Ribosyl Cyclase 1
Adprc 1
Cyclic Adp-Ribose Hydrolase 1
Cadpr Hydrolase 1
T10
Cd Antigen Cd38
Database Links Reactome: R-HSA-196807
Cellular Localisation Cell Surface
Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 protein
2'-Phospho-Adp-Ribosyl Cyclase protein
2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase protein
2'-Phospho-Cyclic-Adp-Ribose Transferase protein
Adp-Ribosyl Cyclase 1 protein
Adprc 1 protein
Cyclic Adp-Ribose Hydrolase 1 protein
Cadpr Hydrolase 1 protein
T10 protein
Cd Antigen Cd38 protein
CD38 protein

Information sourced from Uniprot.org

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