Human CD34 protein (Recombinant) (C-hFc&His) (STJP001349)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CD34 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser32-Thr290) of human CD34 (Accession #NP_001020280.1) fused with a Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CD34-C-hFc&His protein was developed in hek293 cells using the region Ser32-Thr290. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | CD34 |
| Gene ID | 947 |
| Uniprot ID | CD34_HUMAN |
| Immunogen | Recombinant Human CD34 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser32-Thr290) of human CD34 (Accession #NP_001020280.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Ser32-Thr290 |
| Immunogen Sequence | SLDNNGTATPELPTQGTFSN VSTNVSYQETTTPSTLGSTS LHPVSQHGNEATTNITETTV KFTSTSVITSVYGNTNSSVQ SQTSVISTVFTTPANVSTPE TTLKPSLSPGNVSDLSTTST SLATSPTKPYTSSSPILSDI KAEIKCSGIREVKLTQGICL EQNKTSSCAEFKKDRGEGLA RVLCGEEQADADAGAQVCSL LLAQSEVRPQCLLLVLANRT EISSKLQLMKKHQSDLKKL |
Additional Info
| Post Translational Modifications | Highly glycosylated. Phosphorylated on serine residues by PKC. |
| Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| Protein Name | Hematopoietic Progenitor Cell Antigen Cd34Cd Antigen Cd34 |
| Database Links | Reactome: R-HSA-198933 P28906-1 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Hematopoietic Progenitor Cell Antigen Cd34 proteinCd Antigen Cd34 proteinCD34 protein |
Information sourced from Uniprot.org