Human CD337/NKp30 protein (Recombinant-Active) (C-His) (STJP011719)

Name: Human CD337/NKp30 protein (Recombinant-Active) (C-His) (STJP011719)
SKU: STJP011719-100
Price: 604.2 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP011719-100

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Short Description	Recombinant-Active-Human CD337/NKp30-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Measured by its binding ability in a functional ELISA. When recombinant human B7-H6 is Immobilised at 4 µg/mL (100 µL/well) , recombinant human CD337/NKp30 binds with an ED50 of 0.60-7.20 µg/mL.

Function	Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Protein Name	Natural Cytotoxicity Triggering Receptor 3 Activating Natural Killer Receptor P30 Natural Killer Cell P30-Related Protein Nk-P30 Nkp30 Cd Antigen Cd337
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Natural Cytotoxicity Triggering Receptor 3 protein Activating Natural Killer Receptor P30 protein Natural Killer Cell P30-Related Protein protein Nk-P30 protein Nkp30 protein Cd Antigen Cd337 protein NCR3 protein 1C7 protein LY117 protein

Information sourced from Uniprot.org