Human CD328/SIGLEC7 protein (Recombinant) (N-His) (STJP008856)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD328/SIGLEC7-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SIGLEC7 |
| Gene ID | 27036 |
| Uniprot ID | SIGL7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp25-Gln338 |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 7Siglec-7Adhesion Inhibitory Receptor Molecule 1Airm-1Cdw328D-SiglecQa79 Membrane ProteinP75Cd Antigen Cd328 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 7 proteinSiglec-7 proteinAdhesion Inhibitory Receptor Molecule 1 proteinAirm-1 proteinCdw328 proteinD-Siglec proteinQa79 Membrane Protein proteinP75 proteinCd Antigen Cd328 proteinSIGLEC7 proteinAIRM1 protein |
Information sourced from Uniprot.org