Human CD325/CDH2 protein (Recombinant) (N-His) (STJP004239)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD325/CDH2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CDH2 |
| Gene ID | 1000 |
| Uniprot ID | CADH2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp160-Ala724 |
Additional Info
| Function | Calcium-dependent cell adhesion protein.preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Protein Name | Cadherin-2Cdw325Neural CadherinN-CadherinCd Antigen Cd325 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-418990Reactome: R-HSA-525793Reactome: R-HSA-8957275Reactome: R-HSA-9926550 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSarcolemmaCell JunctionCell SurfaceDesmosomeAdherens JunctionColocalizes With Tmem65 At The Intercalated Disk In CardiomyocytesColocalizes With Obscn At The Intercalated Disk And At Sarcolemma In Cardiomyocytes |
| Alternative Protein Names | Cadherin-2 proteinCdw325 proteinNeural Cadherin proteinN-Cadherin proteinCd Antigen Cd325 proteinCDH2 proteinCDHN proteinNCAD protein |
Information sourced from Uniprot.org