Human CD319/SLAMF7 protein (Recombinant) (C-mFc) (STJP013594)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD319/SLAMF7-C-mFc protein was developed from mammalian cells and has a target region of C-mFc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | SLAMF7 |
| Gene ID | 57823 |
| Uniprot ID | SLAF7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser23-Met226 |
Additional Info
| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines. Isoform 3 does not mediate any NK cell activation. |
| Protein Name | Slam Family Member 7Cd2 Subset 1Cd2-Like Receptor-Activating Cytotoxic CellsCraccMembrane Protein Foap-12Novel Ly9Protein 19aCd Antigen Cd319 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Slam Family Member 7 proteinCd2 Subset 1 proteinCd2-Like Receptor-Activating Cytotoxic Cells proteinCracc proteinMembrane Protein Foap-12 proteinNovel Ly9 proteinProtein 19a proteinCd Antigen Cd319 proteinSLAMF7 proteinCS1 proteinUNQ576 proteinPRO1138 protein |
Information sourced from Uniprot.org