Human CD316/IGSF8 protein (Recombinant) (C-His) (STJP007123)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD316/IGSF8-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IGSF8 |
| Gene ID | 93185 |
| Uniprot ID | IGSF8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Thr579 |
Additional Info
| Function | Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Protein Name | Immunoglobulin Superfamily Member 8Igsf8Cd81 Partner 3Glu-Trp-Ile Ewi Motif-Containing Protein 2Ewi-2Keratinocytes-Associated Transmembrane Protein 4Kct-4Lir-D1Prostaglandin Regulatory-Like ProteinPgrlCd Antigen Cd316 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinColocalizes With Cd81 At The Immune Synapse |
| Alternative Protein Names | Immunoglobulin Superfamily Member 8 proteinIgsf8 proteinCd81 Partner 3 proteinGlu-Trp-Ile Ewi Motif-Containing Protein 2 proteinEwi-2 proteinKeratinocytes-Associated Transmembrane Protein 4 proteinKct-4 proteinLir-D1 proteinProstaglandin Regulatory-Like Protein proteinPgrl proteinCd Antigen Cd316 proteinIGSF8 proteinCD81P3 proteinEWI2 proteinKCT4 protein |
Information sourced from Uniprot.org