Human CD300a protein (Recombinant-Active) (C-hFc-His) (STJP012311)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD300a-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells. The ED50 for this effect is 1-5 µg/mL. |
Target Information
| Gene Symbol | CD300A |
| Gene ID | 11314 |
| Uniprot ID | CLM8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu18-Gln178 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine. N-glycosylated. |
| Function | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. |
| Protein Name | Cmrf35-Like Molecule 8Clm-8Cd300 Antigen-Like Family Member ACmrf-35-H9Cmrf35-H9Cmrf35-HIrc1/Irc2Immunoglobulin Superfamily Member 12Igsf12Inhibitory Receptor Protein 60Irp60Nk Inhibitory ReceptorCd Antigen Cd300a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cmrf35-Like Molecule 8 proteinClm-8 proteinCd300 Antigen-Like Family Member A proteinCmrf-35-H9 proteinCmrf35-H9 proteinCmrf35-H proteinIrc1/Irc2 proteinImmunoglobulin Superfamily Member 12 proteinIgsf12 proteinInhibitory Receptor Protein 60 proteinIrp60 proteinNk Inhibitory Receptor proteinCd Antigen Cd300a proteinCD300A proteinCMRF35H proteinIGSF12 proteinHSPC083 protein |
Information sourced from Uniprot.org