Human CD299/CLEC4M protein (Recombinant-Active) (N-hFc) (STJP012262)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD299/CLEC4M-N-hFc protein was developed from mammalian cells and has a target region of N-hFc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by the ability of the Immobilised protein to support the adhesion of ICAM-3 expressing CHO Chinese hamster ovary cells. When 5 x 10^4 cells/well are added to rhCD299/CLEC4M coated plates (5 µg/mL with 100 µL/well) , approximately 40%-70% of |
Target Information
| Gene Symbol | CLEC4M |
| Gene ID | 10332 |
| Uniprot ID | CLC4M_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser73-Glu376 |
Additional Info
| Function | Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. (Microbial infection) Acts as an attachment receptor for HIV-1. (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. (Microbial infection) Acts as an attachment receptor for Influenzavirus. (Microbial infection) Acts as an attachment receptor for SARS-CoV. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. |
| Protein Name | C-Type Lectin Domain Family 4 Member MCd209 Antigen-Like Protein 1Dc-Sign-Related ProteinDc-SignrDendritic Cell-Specific Icam-3-Grabbing Non-Integrin 2Dc-Sign2Liver/Lymph Node-Specific Icam-3-Grabbing Non-IntegrinL-SignCd Antigen Cd299 |
| Database Links | Reactome: R-HSA-9833110 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 5: SecretedIsoform 6: SecretedIsoform 7: SecretedIsoform 10: Secreted |
| Alternative Protein Names | C-Type Lectin Domain Family 4 Member M proteinCd209 Antigen-Like Protein 1 proteinDc-Sign-Related Protein proteinDc-Signr proteinDendritic Cell-Specific Icam-3-Grabbing Non-Integrin 2 proteinDc-Sign2 proteinLiver/Lymph Node-Specific Icam-3-Grabbing Non-Integrin proteinL-Sign proteinCd Antigen Cd299 proteinCLEC4M proteinCD209L proteinCD209L1 proteinCD299 protein |
Information sourced from Uniprot.org