Human CD276/B7-H3 protein (Recombinant-Active) (C-His) (STJP012141)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD276/B7-H3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Immobilised human CD276/B7-H3 at 2 Mu g/mL (100 Mu L/well) can bind Anti-human B7-H3 Antibody with a linear range of 1-4 ng/mL. |
Target Information
| Gene Symbol | CD276 |
| Gene ID | 80381 |
| Uniprot ID | CD276_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu29-Pro245 |
Additional Info
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen4ig-B7-H3B7 Homolog 3B7-H3Costimulatory MoleculeCd Antigen Cd276 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd276 Antigen protein4ig-B7-H3 proteinB7 Homolog 3 proteinB7-H3 proteinCostimulatory Molecule proteinCd Antigen Cd276 proteinCD276 proteinB7H3 proteinPSEC0249 proteinUNQ309 proteinPRO352 protein |
Information sourced from Uniprot.org