Human CD275/B7-H2 protein (Recombinant-Active) (C-His) (STJP011743)

Name: Human CD275/B7-H2 protein (Recombinant-Active) (C-His) (STJP011743)
SKU: STJP011743-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP011743-100

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Short Description	Recombinant-Active-Human CD275/B7-H2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Immobilised human CD275/B7-H2 at 1 Mu g/mL (100 Mu L/well) can bind human ICOS/CD278 with a linear range of 2-15 ng/mL.

Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP).
Protein Name	Icos Ligand B7 Homolog 2 B7-H2 B7-Like Protein Gl50 B7-Related Protein 1 B7rp-1 Cd Antigen Cd275
Database Links	Reactome: R-HSA-9927354
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane
Alternative Protein Names	Icos Ligand protein B7 Homolog 2 protein B7-H2 protein B7-Like Protein Gl50 protein B7-Related Protein 1 protein B7rp-1 protein Cd Antigen Cd275 protein ICOSLG protein B7H2 protein B7RP1 protein ICOSL protein KIAA0653 protein

Information sourced from Uniprot.org