Human CD27 Ligand/CD70 Trimer protein (Recombinant) (N-His) {Biotin} (STJP001718)
SPECIFICATIONS
HostHEK293
ConjugationBiotin
ImmunogenDNA sequence encoding Human CD27 Ligand/CD70 Trimer (Primary Amine Labeling) including a N-His tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
General Information
| Short Description | Recombinant-Human CD27 Ligand/CD70 Trimer-N-His protein was developed from hek293 and has a target region of N-His. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Formulation | Lyophilised from 0.2 ยตm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20ยฐC. |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ยตg (1EU/ยตg). |
Target Information
| Gene Symbol | CD70 |
| Gene ID | 970 |
| Uniprot ID | CD70_HUMAN |
| Immunogen | DNA sequence encoding Human CD27 Ligand/CD70 Trimer (Primary Amine Labeling) including a N-His tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Immunogen Region | Leu50-Pro193 |
Additional Info
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
| Protein Name | Cd70 AntigenCd27 LigandCd27-LTumor Necrosis Factor Ligand Superfamily Member 7Cd Antigen Cd70 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Cd70 Antigen proteinCd27 Ligand proteinCd27-L proteinTumor Necrosis Factor Ligand Superfamily Member 7 proteinCd Antigen Cd70 proteinCD70 proteinCD27L proteinCD27LG proteinTNFSF7 protein |
Information sourced from Uniprot.org