Human CD266/TNFRSF12A protein (Recombinant-Active) (C-hFc-His) (STJP012284)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD266/TNFRSF12A-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit TWEAK-induced apoptosis in human colon adenocarcinoma cells (HT-29). The ED50 for this effect is 2-10 ug/mL in the presence of human TWEAK. |
Target Information
| Gene Symbol | TNFRSF12A |
| Gene ID | 51330 |
| Uniprot ID | TNR12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu28-Trp79 |
Additional Info
| Function | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 12aFibroblast Growth Factor-Inducible Immediate-Early Response Protein 14Fgf-Inducible 14Tweak-ReceptorTweakrCd Antigen Cd266 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 12a proteinFibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 proteinFgf-Inducible 14 proteinTweak-Receptor proteinTweakr proteinCd Antigen Cd266 proteinTNFRSF12A proteinFN14 protein |
Information sourced from Uniprot.org