Human CD257/BAFF/TNFSF13B/BLYS protein (Recombinant-Active) (N-Fc) (STJP012770)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD257/BAFF/TNFSF13B/BLYS-N-Fc protein was developed from mammalian cells and has a target region of N-Fc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 15% Trehalose, 4% Mannitol, 0.05% Tween 80, 10 mM Methionine, pH 8.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | TNFSF13B |
| Gene ID | 10673 |
| Uniprot ID | TN13B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala134-Leu285 |
Additional Info
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB Lymphocyte StimulatorBlysB-Cell-Activating FactorBaffDendritic Cell-Derived Tnf-Like MoleculeTnf- And Apol-Related Leukocyte Expressed Ligand 1Tall-1Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 13b proteinB Lymphocyte Stimulator proteinBlys proteinB-Cell-Activating Factor proteinBaff proteinDendritic Cell-Derived Tnf-Like Molecule proteinTnf- And Apol-Related Leukocyte Expressed Ligand 1 proteinTall-1 proteinCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form proteinTNFSF13B proteinBAFF proteinBLYS proteinTALL1 proteinTNFSF20 proteinZTNF4 proteinUNQ401 proteinPRO738 protein |
Information sourced from Uniprot.org