| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CD247/CD3Z-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications. |
| Formulation: | 0.01M PBS, pH 7.4. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CD247 |
| Gene ID: | 919 |
| Uniprot ID: | CD3Z_HUMAN |
| Immunogen Region: | Arg52-Arg164 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. |
| Function | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). |
| Protein Name | T-Cell Surface Glycoprotein Cd3 Zeta ChainT-Cell Receptor T3 Zeta ChainCd Antigen Cd247 |
| Database Links | Reactome: R-HSA-164944 P20963-1Reactome: R-HSA-198933 P20963-1Reactome: R-HSA-202424 P20963-1Reactome: R-HSA-202427 P20963-1Reactome: R-HSA-202430 P20963-1Reactome: R-HSA-202433 P20963-1Reactome: R-HSA-2029481 P20963-1Reactome: R-HSA-2029482 P20963-1Reactome: R-HSA-2029485 P20963-1Reactome: R-HSA-389948 P20963-1Reactome: R-HSA-9664323 P20963-1Reactome: R-HSA-9664422 P20963-1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | T-Cell Surface Glycoprotein Cd3 Zeta Chain proteinT-Cell Receptor T3 Zeta Chain proteinCd Antigen Cd247 proteinCD247 proteinCD3Z proteinT3Z proteinTCRZ protein |
Information sourced from Uniprot.org