Human CD24 protein (Recombinant) (C-mFc) {Biotin} (STJP001668)
SPECIFICATIONS
HostHEK293
ConjugationBiotin
ImmunogenDNA sequence encoding Human CD24 (Primary Amine Labeling) including a C-mFc tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
General Information
| Short Description | Recombinant-Human CD24-C-mFc protein was developed from hek293 and has a target region of C-mFc. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Formulation | Lyophilised from 0.2 ยตm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20ยฐC. |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ยตg (1EU/ยตg). |
Target Information
| Gene Symbol | CD24 |
| Gene ID | 100133941 |
| Uniprot ID | CD24_HUMAN |
| Immunogen | DNA sequence encoding Human CD24 (Primary Amine Labeling) including a C-mFc tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Immunogen Region | Ser27-Gly59 |
Additional Info
| Post Translational Modifications | Extensively O-glycosylated. |
| Function | May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. |
| Protein Name | Signal Transducer Cd24Small Cell Lung Carcinoma Cluster 4 AntigenCd Antigen Cd24 |
| Database Links | Reactome: R-HSA-373760 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Signal Transducer Cd24 proteinSmall Cell Lung Carcinoma Cluster 4 Antigen proteinCd Antigen Cd24 proteinCD24 proteinCD24A protein |
Information sourced from Uniprot.org