Human CD233/SLC4A1 protein (Recombinant) (N-His) (STJP003599)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD233/SLC4A1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC4A1 |
| Gene ID | 6521 |
| Uniprot ID | B3AT_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala35-Ser290 |
Additional Info
| Post Translational Modifications | Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation. Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation. N-glycosylated. |
| Function | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane.required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes. Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes. |
| Protein Name | Band 3 Anion Transport ProteinAnion Exchange Protein 1Ae 1Anion Exchanger 1Solute Carrier Family 4 Member 1Cd Antigen Cd233 |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-425381Reactome: R-HSA-5619050 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneDetected In The Erythrocyte Cell Membrane And On The Basolateral Membrane Of Alpha-Intercalated Cells In The Collecting Duct In The Kidney |
| Alternative Protein Names | Band 3 Anion Transport Protein proteinAnion Exchange Protein 1 proteinAe 1 proteinAnion Exchanger 1 proteinSolute Carrier Family 4 Member 1 proteinCd Antigen Cd233 proteinSLC4A1 proteinAE1 proteinDI proteinEPB3 protein |
Information sourced from Uniprot.org