Human CD222/IGF2R protein (Recombinant) (C-His) (STJP007030)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD222/IGF2R-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IGF2R |
| Gene ID | 3482 |
| Uniprot ID | MPRI_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp1365 |
Additional Info
| Function | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Protein Name | Cation-Independent Mannose-6-Phosphate ReceptorCi Man-6-P ReceptorCi-MprM6pr300 Kda Mannose 6-Phosphate ReceptorMpr 300Insulin-Like Growth Factor 2 ReceptorInsulin-Like Growth Factor Ii ReceptorIgf-Ii ReceptorM6p/Igf2 ReceptorM6p/Igf2rCd Antigen Cd222 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneMainly Localized In The Golgi At Steady State And Not Detectable In LysosomeColocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Protein Names | Cation-Independent Mannose-6-Phosphate Receptor proteinCi Man-6-P Receptor proteinCi-Mpr proteinM6pr protein300 Kda Mannose 6-Phosphate Receptor proteinMpr 300 proteinInsulin-Like Growth Factor 2 Receptor proteinInsulin-Like Growth Factor Ii Receptor proteinIgf-Ii Receptor proteinM6p/Igf2 Receptor proteinM6p/Igf2r proteinCd Antigen Cd222 proteinIGF2R proteinMPRI protein |
Information sourced from Uniprot.org