Human CD218a/IL18R1 protein (Recombinant-Active) (C-hFc-His) (STJP011772)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD218a/IL18R1-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit the recombinant human IL-18 induced response on human acute myelogenous leukemia cells (KG-1) in the presence of recombinant human IL-18 R beta/IL-1 R7. The ED50 for this effect is 0.400-4.00 Mu g/mL. |
Target Information
| Gene Symbol | IL18R1 |
| Gene ID | 8809 |
| Uniprot ID | IL18R_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu20-Arg329 |
Additional Info
| Post Translational Modifications | N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex. |
| Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. |
| Protein Name | Interleukin-18 Receptor 1Il-18r-1Il-18r1Cd218 Antigen-Like Family Member ACdw218aIl1 Receptor-Related ProteinIl-1rrpIl1r-RpInterleukin-18 Receptor AlphaIl-18r-AlphaIl-18ralphaCd Antigen Cd218a |
| Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-18 Receptor 1 proteinIl-18r-1 proteinIl-18r1 proteinCd218 Antigen-Like Family Member A proteinCdw218a proteinIl1 Receptor-Related Protein proteinIl-1rrp proteinIl1r-Rp proteinInterleukin-18 Receptor Alpha proteinIl-18r-Alpha proteinIl-18ralpha proteinCd Antigen Cd218a proteinIL18R1 proteinIL1RRP protein |
Information sourced from Uniprot.org