Human CD21/CR2 protein (Recombinant) (N-GST) (STJP004266)

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STJP004266
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD21/CR2-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CR2
Gene ID: 1380
Uniprot ID: CR2_HUMAN
Immunogen Region: Lys729-Asp958
Immunogen: Homo sapiens (Human)
Function Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Induces also specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Protein Name Complement Receptor Type 2
Cr2
Complement C3d Receptor
Epstein-Barr Virus Receptor
Ebv Receptor
Cd Antigen Cd21
Database Links Reactome: R-HSA-977606
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Complement Receptor Type 2 protein
Cr2 protein
Complement C3d Receptor protein
Epstein-Barr Virus Receptor protein
Ebv Receptor protein
Cd Antigen Cd21 protein
CR2 protein
C3DR protein

Information sourced from Uniprot.org

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