Human CD200R1 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020242)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human CD200R1 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala27-Leu266) of Human CD200R1 fused with a His and Avi tag at the C-terminal.
General Information
| Short Description | Recombinant-Human CD200R1-C-His&Avi protein was developed in hek293 cells using the region Ala27-Leu266. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD200R1 |
| Gene ID | 131450 |
| Uniprot ID | MO2R1_HUMAN |
| Immunogen | Biotinylated Recombinant Human CD200R1 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala27-Leu266) of Human CD200R1 fused with a His and Avi tag at the C-terminal. |
| Immunogen Region | Ala27-Leu266 |
Additional Info
| Tissue Specificity | Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells. |
| Function | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. |
| Protein Name | Cell Surface Glycoprotein Cd200 Receptor 1Cd200 Cell Surface Glycoprotein ReceptorCell Surface Glycoprotein Ox2 Receptor 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 4: Cell MembraneIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Protein Names | Cell Surface Glycoprotein Cd200 Receptor 1 proteinCd200 Cell Surface Glycoprotein Receptor proteinCell Surface Glycoprotein Ox2 Receptor 1 proteinCD200R1 proteinCD200R proteinCRTR2 proteinMOX2R proteinOX2R proteinUNQ2522 proteinPRO6015 protein |
Information sourced from Uniprot.org