| Host: |
E.coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
CD19 |
| Gene ID: |
930 |
| Uniprot ID: |
CD19_HUMAN |
| Immunogen Region: |
Pro21-Lys291 |
| Immunogen: |
Recombinant Human CD19 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Pro21-Lys291) of human CD19 (Accession #NP_001761.3) fused with an 6×His tag at the C-terminus. |
| Immunogen Sequence: |
QALGQDMVSQEATNCSSSSS SFSSPSSAGRHVRSYNHLQG DVRWRRLFSFTKYFLTIEKN GKVSGTKNEDCPYSVLEITS VEIGVVAVKAINSNYYLAMN KKGKLYGSKEFNNDCKLKER IEENGYNTYASFNWQHNGRQ MYVALNGKGAPRRGQKTRRK NTSAHFLPMTIQT |
| Tissue Specificity | Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels. |
| Function | Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. |
| Protein Name | B-Lymphocyte Antigen Cd19B-Lymphocyte Surface Antigen B4Differentiation Antigen Cd19T-Cell Surface Antigen Leu-12Cd Antigen Cd19 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-198933Reactome: R-HSA-2219530Reactome: R-HSA-6811558Reactome: R-HSA-977606Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Protein Names | B-Lymphocyte Antigen Cd19 proteinB-Lymphocyte Surface Antigen B4 proteinDifferentiation Antigen Cd19 proteinT-Cell Surface Antigen Leu-12 proteinCd Antigen Cd19 proteinCD19 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
