Human CD16b (FcgR3b) protein (Recombinant) (STJP000294)

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STJP000294
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD16b (FcgR3b)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised 0.2 Mu m filtered PBS solution, pH7.4 containing 5% trehalose.
Dilution Range: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol: FCGR3B
Gene ID: 2215
Uniprot ID: FCG3B_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding Human extracellular domain of human CD16bincluding a C-terminal 6His tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Post Translational Modifications Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage.
Function Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B
Fc-Gamma Riii-Beta
Cd16-I
Fc-Gamma Riii
Fc-Gamma Riiib
Fcriii
Fcriiib
Fcr-10
Igg Fc Receptor Iii-1
Cd Antigen Cd16b
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Secreted After Cleavage
Alternative Protein Names Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B protein
Fc-Gamma Riii-Beta protein
Cd16-I protein
Fc-Gamma Riii protein
Fc-Gamma Riiib protein
Fcriii protein
Fcriiib protein
Fcr-10 protein
Igg Fc Receptor Iii-1 protein
Cd Antigen Cd16b protein
FCGR3B protein
CD16B protein
FCG3 protein
FCGR3 protein
IGFR3 protein

Information sourced from Uniprot.org

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