Human CD16b (FcgR3b) protein (Recombinant) (STJP000294)

Name: Human CD16b (FcgR3b) protein (Recombinant) (STJP000294)
SKU: STJP000294
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostHEK293

ConjugationUnconjugated

ImmunogenOptimized DNA sequence encoding Human extracellular domain of human CD16bincluding a C-terminal 6His tag was expressed in HEK293 cells. NA

STJP000294

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Short Description	Recombinant-Human CD16b (FcgR3b)-protein was developed from hek293. For use in research applications.
Host	HEK293
Note	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.
Formulation	Lyophilised 0.2 Mu m filtered PBS solution, pH7.4 containing 5% trehalose.
Storage Instruction	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles. NA
Endotoxin	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA

Gene Symbol	FCGR3B
Gene ID	2215
Uniprot ID	FCG3B_HUMAN
Immunogen	Optimized DNA sequence encoding Human extracellular domain of human CD16bincluding a C-terminal 6His tag was expressed in HEK293 cells. NA
Immunogen Region	ECD

Tissue Specificity	Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Post Translational Modifications	Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3. The soluble form is produced by a proteolytic cleavage.
Function	Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Protein Name	Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B Fc-Gamma Riii-Beta Cd16-I Fc-Gamma Riii Fc-Gamma Riiib Fcriii Fcriiib Fcr-10 Igg Fc Receptor Iii-1 Cd Antigen Cd16b
Database Links	Reactome: R-HSA-163125 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Secreted Secreted After Cleavage
Alternative Protein Names	Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-B protein Fc-Gamma Riii-Beta protein Cd16-I protein Fc-Gamma Riii protein Fc-Gamma Riiib protein Fcriii protein Fcriiib protein Fcr-10 protein Igg Fc Receptor Iii-1 protein Cd Antigen Cd16b protein FCGR3B protein CD16B protein FCG3 protein FCGR3 protein IGFR3 protein

Information sourced from Uniprot.org