Human CD158d/KIR2DL4 protein (Recombinant) (C-His) (STJP007128)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD158d/KIR2DL4-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KIR2DL4 |
| Gene ID | 3805 |
| Uniprot ID | KI2L4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-His242 |
Additional Info
| Function | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl4Cd158 Antigen-Like Family Member DG9pKiller Cell Inhibitory Receptor 103asKir-103asMhc Class I Nk Cell Receptor Kir103asCd Antigen Cd158d |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEarly Endosome Membrane |
| Alternative Protein Names | Killer Cell Immunoglobulin-Like Receptor 2dl4 proteinCd158 Antigen-Like Family Member D proteinG9p proteinKiller Cell Inhibitory Receptor 103as proteinKir-103as proteinMhc Class I Nk Cell Receptor Kir103as proteinCd Antigen Cd158d proteinKIR2DL4 proteinCD158D proteinKIR103AS protein |
Information sourced from Uniprot.org