Human CD156b/ADAM17 protein (Recombinant) (C-His) (STJP007081)
SPECIFICATIONS
HostInsect Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD156b/ADAM17-C-His protein was developed from insect cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Insect Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8Β°C for frequent use. Store at-20 to-80Β°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ADAM17 |
| Gene ID | 6868 |
| Uniprot ID | ADA17_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg215-Asn671 |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at Thr-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding. |
| Function | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity. Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 17Adam 17Snake Venom-Like ProteaseTnf-Alpha ConvertaseTnf-Alpha-Converting EnzymeCd Antigen Cd156b |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-1442490Reactome: R-HSA-177929Reactome: R-HSA-193692Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-5362798Reactome: R-HSA-75893Reactome: R-HSA-9662834Reactome: R-HSA-982772 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Disintegrin And Metalloproteinase Domain-Containing Protein 17 proteinAdam 17 proteinSnake Venom-Like Protease proteinTnf-Alpha Convertase proteinTnf-Alpha-Converting Enzyme proteinCd Antigen Cd156b proteinADAM17 proteinCSVP proteinTACE protein |
Information sourced from Uniprot.org