Human CD144/CDH5 protein (Recombinant) (C-Fc) (STJP007065)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD144/CDH5-C-Fc protein was developed from mammalian cells for the region C-Fc. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CDH5 |
| Gene ID | 1003 |
| Uniprot ID | CADH5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gln593 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Associates with CTNND1/p120-catenin to control CADH5 endocytosis. |
| Protein Name | Cadherin-57b4 AntigenVascular Endothelial CadherinVe-CadherinCd Antigen Cd144 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmFound At Cell-Cell Boundaries And Probably At Cell-Matrix BoundariesKrit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions |
| Alternative Protein Names | Cadherin-5 protein7b4 Antigen proteinVascular Endothelial Cadherin proteinVe-Cadherin proteinCd Antigen Cd144 proteinCDH5 protein |
Information sourced from Uniprot.org