Human CD124/IL4R protein (Recombinant) (C-Fc) (STJP004398)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD124/IL4R-C-Fc protein was developed from mammalian cells for the region C-Fc. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IL4R |
| Gene ID | 3566 |
| Uniprot ID | IL4RA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-His232 |
Additional Info
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit AlphaSoluble Il-4 Receptor Subunit AlphaSoluble Il-4r-AlphaSil4ralpha/ProtIl-4-Binding ProteinIl4-Bp |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Interleukin-4 Receptor Subunit Alpha proteinIl-4 Receptor Subunit Alpha proteinIl-4r Subunit Alpha proteinIl-4r-Alpha proteinIl-4ra proteinCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha proteinSoluble Il-4 Receptor Subunit Alpha proteinSoluble Il-4r-Alpha proteinSil4ralpha/Prot proteinIl-4-Binding Protein proteinIl4-Bp proteinIL4R proteinIL4RA protein582J2.1 protein |
Information sourced from Uniprot.org