Human CD121b/IL1R2 protein (Recombinant) (C-His) (STJP006598)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD121b/IL1R2-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IL1R2 |
| Gene ID | 7850 |
| Uniprot ID | IL1R2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu343 |
Additional Info
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-1 Receptor Type 2 proteinIl-1r-2 proteinIl-1rt-2 proteinIl-1rt2 proteinCd121 Antigen-Like Family Member B proteinCdw121b proteinIl-1 Type Ii Receptor proteinInterleukin-1 Receptor Beta proteinIl-1r-Beta proteinInterleukin-1 Receptor Type Ii proteinCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form proteinMil-1r2 proteinMil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form proteinSil-1r2 proteinSil-1rii proteinIL1R2 proteinIL1RB protein |
Information sourced from Uniprot.org