Human CD120b/TNFRSF1B/TNFR2 protein (Recombinant) (N-His) (STJP004279)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD120b/TNFRSF1B/TNFR2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TNFRSF1B |
| Gene ID | 7133 |
| Uniprot ID | TNR1B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu23-Asp257 |
Additional Info
| Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1bTumor Necrosis Factor Receptor 2Tnf-R2Tumor Necrosis Factor Receptor Type IiTnf-RiiTnfr-IiP75P80 Tnf-Alpha ReceptorCd Antigen Cd120bEtanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2Tbp-2Tbpii |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedTumor Necrosis Factor-Binding Protein 2: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1b proteinTumor Necrosis Factor Receptor 2 proteinTnf-R2 proteinTumor Necrosis Factor Receptor Type Ii proteinTnf-Rii proteinTnfr-Ii proteinP75 proteinP80 Tnf-Alpha Receptor proteinCd Antigen Cd120b proteinEtanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 proteinTbp-2 proteinTbpii proteinTNFRSF1B proteinTNFBR proteinTNFR2 protein |
Information sourced from Uniprot.org