Human CD120a/TNFRSF1A/TNFR1 protein (Recombinant-Active) (C-Fc) (STJP012507)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD120a/TNFRSF1A/TNFR1-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | TNFRSF1A |
| Gene ID | 7132 |
| Uniprot ID | TNR1A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu30-Thr211 |
Additional Info
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1Tbpi |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5626978Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus MembraneSecretedA Secreted Form Is Produced Through Proteolytic ProcessingIsoform 4: SecretedLacks A Golgi-Retention MotifIs Not Membrane Bound And Therefore Is Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1a proteinTumor Necrosis Factor Receptor 1 proteinTnf-R1 proteinTumor Necrosis Factor Receptor Type I proteinTnf-Ri proteinTnfr-I proteinP55 proteinP60 proteinCd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 proteinTbpi proteinTNFRSF1A proteinTNFAR proteinTNFR1 protein |
Information sourced from Uniprot.org