Human CD119 (IFNGR1) protein (Recombinant) (STJP000438)

Conjugation:	Unconjugated
Formulation:	0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction:	Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA

Gene Symbol:	IFNGR1
Gene ID:	3459
Uniprot ID:	INGR1_HUMAN
Immunogen Region:	ECD
Immunogen:	Optimized DNA sequence encoding extracellular domain of Human IFN-gamma receptor (IFNGR1) including a C-terminal 6His tag was expressed in HEK293 cells. NA

Post Translational Modifications	Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-457 is required for IFNG receptor signal transduction. Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner. Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation. Proteasomally degraded through 'Lys-48'-mediated ubiquitination. Ubiquitination is necessary for efficient IFNGR1 signaling.
Function	Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Protein Name	Interferon Gamma Receptor 1 Ifn-Gamma Receptor 1 Ifn-Gamma-R1 Cdw119 Interferon Gamma Receptor Alpha-Chain Ifn-Gamma-R-Alpha Cd Antigen Cd119
Database Links	Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-9679191 Reactome: R-HSA-9732724
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Interferon Gamma Receptor 1 protein Ifn-Gamma Receptor 1 protein Ifn-Gamma-R1 protein Cdw119 protein Interferon Gamma Receptor Alpha-Chain protein Ifn-Gamma-R-Alpha protein Cd Antigen Cd119 protein IFNGR1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance