| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CD114 (GCSFR)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Immunoreactivity: |
The activity of Recombinant human CD114 was measured by its ability to inhibit the G-CSF induced proliferation of NFS60 mouse myeloid cells. The ED50 for this effect is typically 20-80 ng/mL. NA |
| Gene Symbol: |
CSF3R |
| Gene ID: |
1441 |
| Uniprot ID: |
CSF3R_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding extracellular domain of human CD114 including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. |
| Protein Name | Granulocyte Colony-Stimulating Factor ReceptorG-Csf ReceptorG-Csf-RCd Antigen Cd114 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-9616222Reactome: R-HSA-9674555Reactome: R-HSA-9705462 |
| Cellular Localisation | Isoform 2: SecretedCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Granulocyte Colony-Stimulating Factor Receptor proteinG-Csf Receptor proteinG-Csf-R proteinCd Antigen Cd114 proteinCSF3R proteinGCSFR protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
