Human CD112R/PVRIG protein (Recombinant-Active) (C-hFc) (STJP012158)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD112R/PVRIG-C-hFc protein was developed from mammalian cells and has a target region of C-hFc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant human CD112R/PVRIG is Immobilised at 1 Mu g/mL, 100 Mu L/well, the concentration of recombinant human Nectin-2/CD112 that produces 50% of the optimal binding response is 0.4-2.4 |
Target Information
| Gene Symbol | PVRIG |
| Gene ID | 79037 |
| Uniprot ID | PVRIG_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr41-Leu172 |
Additional Info
| Function | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. |
| Protein Name | Transmembrane Protein PvrigCd112 ReceptorCd112rPoliovirus Receptor-Related Immunoglobulin Domain-Containing Protein |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Transmembrane Protein Pvrig proteinCd112 Receptor proteinCd112r proteinPoliovirus Receptor-Related Immunoglobulin Domain-Containing Protein proteinPVRIG proteinC7orf15 protein |
Information sourced from Uniprot.org