Human CD112 (PRR2) protein (Recombinant) (STJP000667)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenDNA sequence encoding the extracellular domain of Human NECTIN2 including a C-terminal His tag was expressed in HEK293 Cells. NA
General Information
| Short Description | Recombinant-Human CD112 (PRR2)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity | The activity of Recombinant human CD112 was measured in a functional ELISA assay, immobilized recombinant human CD112 at 20 Mu g/ml ( NA |
Target Information
| Gene Symbol | NECTIN2 |
| Gene ID | 5819 |
| Uniprot ID | NECT2_HUMAN |
| Immunogen | DNA sequence encoding the extracellular domain of Human NECTIN2 including a C-terminal His tag was expressed in HEK293 Cells. NA |
| Immunogen Region | ECD |
| Immunogen Sequence | QDVRVQVLPE VRGQLGGTVE LPCHLLPPVP GLYISLVTWQ RPDAPANHQN VAAFHPKMGP SFPSPKPGSE RLSFVSAKQS TGQDTEAELQ DATLALHGLT VEDEGNYTCE FATFPKGSVR GMTWLRVIAK PKNQAEAQKV TFSQDPTTVA LCISKEGRPP ARISWLSSLD WEAKETQVSG TLAGTVTVTS RFTLVPSGRA DGVTVTCKVE HESFEEPALI PVTLSVRY |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebNectin Cell Adhesion Molecule 2Poliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nectin-2 proteinHerpes Virus Entry Mediator B proteinHerpesvirus Entry Mediator B proteinHveb proteinNectin Cell Adhesion Molecule 2 proteinPoliovirus Receptor-Related Protein 2 proteinCd Antigen Cd112 proteinNECTIN2 proteinHVEB proteinPRR2 proteinPVRL2 protein |
Information sourced from Uniprot.org