Human CD100/SEMA4D protein (Recombinant-Active) (C-His) (STJP012218)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD100/SEMA4D-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Immobilised human CD100/SEMA4D at 1 Mu g/mL (100 Mu L/well) can bind anti-CD100/SEMA4D Rabbit mAb with a linear range of 0.012-0.88 ng/mL. |
Target Information
| Gene Symbol | SEMA4D |
| Gene ID | 10507 |
| Uniprot ID | SEM4D_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met22-Arg734 |
Additional Info
| Function | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system.induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway. |
| Protein Name | Semaphorin-4dA8Bb18Gr3Cd Antigen Cd100 |
| Database Links | Reactome: R-HSA-416550Reactome: R-HSA-416572Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Semaphorin-4d proteinA8 proteinBb18 proteinGr3 proteinCd Antigen Cd100 proteinSEMA4D proteinC9orf164 proteinCD100 proteinSEMAJ protein |
Information sourced from Uniprot.org