Human CCM2 protein (Recombinant) (His-Tag) (STJP018596)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CCM2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCM2 |
| Gene ID | 83605 |
| Uniprot ID | CCM2_HUMAN |
| Accession Number | NP_001161407 |
| Immunogen | Human |
| Immunogen Region | 66-353aa |
| Immunogen Sequence |
Additional Info
| Function | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock. |
| Protein Name | Cerebral Cavernous Malformations 2 ProteinMalcavernin |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Cerebral Cavernous Malformations 2 Protein proteinMalcavernin proteinCCM2 proteinC7orf22 proteinPP10187 protein |
Information sourced from Uniprot.org