Human CCL4/MIP-1Beta protein (Recombinant) (C-hFc) (STJP002858)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CCL4/MIP-1Beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Asn92) of human CCL4/MIP-1Beta (Accession #NP_002975.1) fused with and a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CCL4/MIP-1Beta-C-hFc protein was developed in hek293 cells using the region Ala24-Asn92. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | CCL4 |
| Gene ID | 388372/6351 |
| Uniprot ID | CCL4_HUMAN |
| Immunogen | Recombinant Human CCL4/MIP-1Beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Asn92) of human CCL4/MIP-1Beta (Accession #NP_002975.1) fused with and a hFc tag at the C-terminus. |
| Immunogen Region | Ala24-Asn92 |
| Immunogen Sequence | APMGSDPPTACCFSYTARKL PRNFVVDYYETSSLCSQPAV VFQTKRSKQVCADPSESWVQ EYVYDLELN |
Additional Info
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| Protein Name | C-C Motif Chemokine 4G-26 T-Lymphocyte-Secreted ProteinHc21Lymphocyte Activation Gene 1 ProteinLag-1Mip-1-Beta(1-69Macrophage Inflammatory Protein 1-BetaMip-1-BetaPat 744Protein H400Sis-GammaSmall-Inducible Cytokine A4T-Cell Activation Protein 2Act-2 Cleaved Into - Mip-1-Beta(3-69 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 4 proteinG-26 T-Lymphocyte-Secreted Protein proteinHc21 proteinLymphocyte Activation Gene 1 Protein proteinLag-1 proteinMip-1-Beta(1-69 proteinMacrophage Inflammatory Protein 1-Beta proteinMip-1-Beta proteinPat 744 proteinProtein H400 proteinSis-Gamma proteinSmall-Inducible Cytokine A4 proteinT-Cell Activation Protein 2 proteinAct-2 Cleaved Into - Mip-1-Beta(3-69 proteinCCL4 proteinLAG1 proteinMIP1B proteinSCYA4 protein |
Information sourced from Uniprot.org