Human CCL23/MIP-3/MPIF-1 protein (Recombinant) (Tag free) (STJP014542)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CCL23/MIP-3/MPIF-1-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 250mM NaCl, pH 7.2. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CCL23 |
| Gene ID | 6368 |
| Uniprot ID | CCL23_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg46-Asn120 |
Additional Info
| Post Translational Modifications | The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms, CCL23(19-99), CCL23(22-99), CCL23(27-99) and CCL23(30-99) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro. |
| Function | Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23. |
| Protein Name | C-C Motif Chemokine 23Ck-Beta-8Ckb-8Macrophage Inflammatory Protein 3Mip-3Myeloid Progenitor Inhibitory Factor 1Mpif-1Small-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 |
| Database Links | Reactome: R-HSA-416476 P55773-2Reactome: R-HSA-418594 P55773-2Reactome: R-HSA-444473 P55773-2 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 23 proteinCk-Beta-8 proteinCkb-8 proteinMacrophage Inflammatory Protein 3 proteinMip-3 proteinMyeloid Progenitor Inhibitory Factor 1 proteinMpif-1 proteinSmall-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 proteinCCL23 proteinMIP3 proteinMPIF1 proteinSCYA23 protein |
Information sourced from Uniprot.org