Human CCL23/Ck beta 8-1 protein (Recombinant) (No tag) (STJP002903)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human CCL23/Ck beta 8-1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg22-Asn120) of human CCL23/Ck beta 8-1 (Accession #P55773) fused with no additional amino acid.
General Information
| Short Description | Recombinant-Human CCL23/Ck beta 8-1-No tag protein was developed in e.coli using the region Arg22-Asn120. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of 20 mM PB, 250 mM NaCl, pH 7.2. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CCL23 |
| Gene ID | 6368 |
| Uniprot ID | CCL23_HUMAN |
| Immunogen | Recombinant Human CCL23/Ck beta 8-1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg22-Asn120) of human CCL23/Ck beta 8-1 (Accession #P55773) fused with no additional amino acid. |
| Immunogen Region | Arg22-Asn120 |
| Immunogen Sequence | NLNPKKFSIHDQDHKVLVLD SGNLIAVPDKNYIRPEIFFA LASSLSSASAEKGSPILLGV SKGEFCLYCDKDKGQSHPSL QLKKEKLMKLAAQKESARRP FIFYRAQVGSWNMLESAAHP GWFICTSCNCNEPVGVTDKF ENRKHIEFSFQPVCKAEMSP SEVSD |
Additional Info
| Tissue Specificity | High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. |
| Post Translational Modifications | The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms, CCL23(19-99), CCL23(22-99), CCL23(27-99) and CCL23(30-99) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro. |
| Function | Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23. |
| Protein Name | C-C Motif Chemokine 23Ck-Beta-8Ckb-8Macrophage Inflammatory Protein 3Mip-3Myeloid Progenitor Inhibitory Factor 1Mpif-1Small-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 |
| Database Links | Reactome: R-HSA-416476 P55773-2Reactome: R-HSA-418594 P55773-2Reactome: R-HSA-444473 P55773-2 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 23 proteinCk-Beta-8 proteinCkb-8 proteinMacrophage Inflammatory Protein 3 proteinMip-3 proteinMyeloid Progenitor Inhibitory Factor 1 proteinMpif-1 proteinSmall-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 proteinCCL23 proteinMIP3 proteinMPIF1 proteinSCYA23 protein |
Information sourced from Uniprot.org