Human CCL19/MIP-3 beta protein (Recombinant) (C-His) (STJP001992)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CCL19/MIP-3 beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly22-Ser98) of human CCL19/MIP-3 beta (Accession #NP_006265.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CCL19/MIP-3 beta-C-His protein was developed in hek293 cells using the region Gly22-Ser98. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g |
Target Information
| Gene Symbol | CCL19 |
| Gene ID | 6363 |
| Uniprot ID | CCL19_HUMAN |
| Immunogen | Recombinant Human CCL19/MIP-3 beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly22-Ser98) of human CCL19/MIP-3 beta (Accession #NP_006265.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Gly22-Ser98 |
| Immunogen Sequence | GTNDAEDCCLSVTQKPIPGY IVRNFHYLLIKDGCRVPAVV FTTLRGRQLCAPPDQPWVER IIQRLQRTSAKMKRRSS |
Additional Info
| Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 19Beta-Chemokine Exodus-3Ck Beta-11Epstein-Barr Virus-Induced Molecule 1 Ligand ChemokineEbi1 Ligand ChemokineElcMacrophage Inflammatory Protein 3 BetaMip-3-BetaSmall-Inducible Cytokine A19 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 19 proteinBeta-Chemokine Exodus-3 proteinCk Beta-11 proteinEpstein-Barr Virus-Induced Molecule 1 Ligand Chemokine proteinEbi1 Ligand Chemokine proteinElc proteinMacrophage Inflammatory Protein 3 Beta proteinMip-3-Beta proteinSmall-Inducible Cytokine A19 proteinCCL19 proteinELC proteinMIP3B proteinSCYA19 protein |
Information sourced from Uniprot.org