Recombinant Human CCL17/TARC Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 10-15 kDa.

Human CCL17/TARC protein (Recombinant) (No-Tag) (STJP003019)

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STJP003019
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method
Gene Symbol: CCL17
Gene ID: 6361
Uniprot ID: CCL17_HUMAN
Immunogen Region: Ala24-Ser94
Immunogen: Recombinant Recombinant Human CCL17/TARC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Ser94) of Human CCL17/TARC (Accession #NP_002978.1) fused with a His tag at the C-terminus.
Immunogen Sequence: STGSKQRSQNRSKTPKNQEA LRMANVAENSSSDQRQACKK HELYVSFRDLGWQDWIIAPE GYAAYYCEGECAFPLNSYMN ATNHAIVQTLVHFINPETVP KPCCAPTQLNAISVLYFDDS SNVILKKYRNMVVRACGCH
Tissue Specificity Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine. Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells.
Function Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound.
Protein Name C-C Motif Chemokine 17
Cc Chemokine Tarc
Small-Inducible Cytokine A17
Thymus And Activation-Regulated Chemokine
Database Links Reactome: R-HSA-380108
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 17 protein
Cc Chemokine Tarc protein
Small-Inducible Cytokine A17 protein
Thymus And Activation-Regulated Chemokine protein
CCL17 protein
SCYA17 protein
TARC protein

Information sourced from Uniprot.org

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