Human CCL17/TARC protein (Recombinant) (C-hFc&His) (STJP001366)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CCL17/TARC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Ser94) of human CCL17/TARC (Accession #NP_002978.1) fused with a Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CCL17/TARC-C-hFc&His protein was developed in hek293 cells using the region Ala24-Ser94. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | CCL17 |
| Gene ID | 6361 |
| Uniprot ID | CCL17_HUMAN |
| Immunogen | Recombinant Human CCL17/TARC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Ser94) of human CCL17/TARC (Accession #NP_002978.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Ala24-Ser94 |
| Immunogen Sequence | ARGTNVGRECCLEYFKGAIP LRKLKTWYQTSEDCSRDAIV FVTVQGRAICSDPNNKRVKN AVKYLQSLERS |
Additional Info
| Function | Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound. |
| Protein Name | C-C Motif Chemokine 17Cc Chemokine TarcSmall-Inducible Cytokine A17Thymus And Activation-Regulated Chemokine |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 17 proteinCc Chemokine Tarc proteinSmall-Inducible Cytokine A17 proteinThymus And Activation-Regulated Chemokine proteinCCL17 proteinSCYA17 proteinTARC protein |
Information sourced from Uniprot.org