Human CCL16/HCC-4 protein (Recombinant) (C-His) (STJP020077)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CCL16/HCC-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Gln120) of Human CCL16/HCC-4 (Accession # O15467) fused with with His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CCL16/HCC-4-C-His protein was developed in hek293 cells using the region Gln24-Gln120. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method |
Target Information
| Gene Symbol | CCL16 |
| Gene ID | 6360 |
| Uniprot ID | CCL16_HUMAN |
| Immunogen | Recombinant Human CCL16/HCC-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Gln120) of Human CCL16/HCC-4 (Accession # O15467) fused with with His tag at the C-terminus. |
| Immunogen Region | Gln24-Gln120 |
| Immunogen Sequence | QPKVPEWVNTPSTCCLKYYE KVLPRRLVVGYRKALNCHLP AIIFVTKRNREVCTNPNDDW VQEYIKDPNLPLLPTRNLST VKIITAKNGQPQLLNSQ |
Additional Info
| Tissue Specificity | Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. |
| Function | Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. |
| Protein Name | C-C Motif Chemokine 16Chemokine Cc-4Hcc-4Chemokine LecIl-10-Inducible ChemokineLcc-1Liver-Expressed ChemokineLymphocyte And Monocyte ChemoattractantLmcMonotactin-1Mtn-1Ncc-4Small-Inducible Cytokine A16 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 16 proteinChemokine Cc-4 proteinHcc-4 proteinChemokine Lec proteinIl-10-Inducible Chemokine proteinLcc-1 proteinLiver-Expressed Chemokine proteinLymphocyte And Monocyte Chemoattractant proteinLmc proteinMonotactin-1 proteinMtn-1 proteinNcc-4 proteinSmall-Inducible Cytokine A16 proteinCCL16 proteinILINCK proteinNCC4 proteinSCYA16 protein |
Information sourced from Uniprot.org