Human CCL15/MIP-5/HCC-2 protein (Recombinant) (C-6His) (STJP020085)

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STJP020085
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/Mu g of the protein by LAL method
Gene Symbol: CCL15
Gene ID: 6359
Uniprot ID: CCL15_HUMAN
Immunogen Region: Ser46-Ile113
Immunogen: Recombinant Human CCL15/MIP-5/HCC-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser46-Ile113) of Human CCL15/MIP-5/HCC-2 (Accession #NP_116741.2) fused with His at the C-terminus.
Immunogen Sequence: SFHFAADCCTSYISQSIPCS LMKSYFETSSECSKPGVIFL TKKGRQVCAKPSGPGVQDCM KKLKPYSI
Tissue Specificity Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
Post Translational Modifications The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CCL15(22-92), CCL15(25-92) and CCL15(29-92) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro.
Function Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the CCL15.
Protein Name C-C Motif Chemokine 15
Chemokine Cc-2
Hcc-2
Leukotactin-1
Lkn-1
Mip-1 Delta
Macrophage Inflammatory Protein 5
Mip-5
Mrp-2b
Ncc-3
Small-Inducible Cytokine A15 Cleaved Into - Ccl15(22-92 - Ccl15(25-92 - Ccl15(29-92
Database Links
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 15 protein
Chemokine Cc-2 protein
Hcc-2 protein
Leukotactin-1 protein
Lkn-1 protein
Mip-1 Delta protein
Macrophage Inflammatory Protein 5 protein
Mip-5 protein
Mrp-2b protein
Ncc-3 protein
Small-Inducible Cytokine A15 Cleaved Into - Ccl15(22-92 - Ccl15(25-92 - Ccl15(29-92 protein
CCL15 protein
MIP5 protein
NCC3 protein
SCYA15 protein

Information sourced from Uniprot.org

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