Human CCL14/NCC-2 protein (Recombinant) (C-His) (STJP013491)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CCL14/NCC-2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.2. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CCL14 |
| Gene ID | 6358 |
| Uniprot ID | CCL14_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr20-Asn93 |
Additional Info
| Post Translational Modifications | The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated.the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids. |
| Function | Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. |
| Protein Name | C-C Motif Chemokine 14Chemokine Cc-1/Cc-3Hcc-1/Hcc-3Hcc-1(1-74Ncc-2Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 14 proteinChemokine Cc-1/Cc-3 proteinHcc-1/Hcc-3 proteinHcc-1(1-74 proteinNcc-2 proteinSmall-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 proteinCCL14 proteinNCC2 proteinSCYA14 protein |
Information sourced from Uniprot.org