Human CCL14/HCC-1/HCC-3 protein (Recombinant) (No-Tag) (STJP002965)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Recombinant Human CCL14/HCC-1/HCC-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr20-Asn93) of Human CCL14/HCC-1/HCC-3 (Accession #NP_116739.1) fused with His tag at the C-terminu
General Information
| Short Description | Recombinant-Human CCL14/HCC-1/HCC-3-No-Tag protein was developed in e.coli using the region Thr20-Asn93. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.01 EU/ug of the protein by LAL method |
Target Information
| Gene Symbol | CCL14 |
| Gene ID | 6358 |
| Uniprot ID | CCL14_HUMAN |
| Immunogen | Recombinant Recombinant Human CCL14/HCC-1/HCC-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr20-Asn93) of Human CCL14/HCC-1/HCC-3 (Accession #NP_116739.1) fused with His tag at the C-terminu |
| Immunogen Region | Thr20-Asn93 |
| Immunogen Sequence | APLGEVGNYFGVQDAVPFGN VPVLPVDSPVLLSDHLGQSE AGGLPRGPAVTDLDHLKGIL RRRQLYCRTGFHLEIFPNGT IQGTRKDHSRFGILEFISIA VGLVSIRGVDSGLYLGMNEK GELYGSEKLTQECVFREQFE ENWYNTYSSNLYKHVDTGRR YYVALNKDGTPREGTRTKRH QKFTHFLPRPVDPDKVPELY KDILSQS |
Additional Info
| Tissue Specificity | Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. |
| Post Translational Modifications | The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated.the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids. |
| Function | Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. |
| Protein Name | C-C Motif Chemokine 14Chemokine Cc-1/Cc-3Hcc-1/Hcc-3Hcc-1(1-74Ncc-2Small-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 14 proteinChemokine Cc-1/Cc-3 proteinHcc-1/Hcc-3 proteinHcc-1(1-74 proteinNcc-2 proteinSmall-Inducible Cytokine A14 Cleaved Into - Hcc-1(3-74 - Hcc-1(4-74 - Hcc-1(9-74 proteinCCL14 proteinNCC2 proteinSCYA14 protein |
Information sourced from Uniprot.org