| Tissue Specificity | Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. |
| Post Translational Modifications | One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain. |
| Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. |
| Protein Name | C-C Motif Chemokine 13Ck-Beta-10Monocyte Chemoattractant Protein 4Monocyte Chemotactic Protein 4Mcp-4Ncc-1Small-Inducible Cytokine A13 Cleaved Into - C-C Motif Chemokine 13 - Long Chain - C-C Motif Chemokine 13 - Medium Chain - C-C Motif Chemokine 13 - Short Chain |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 13 proteinCk-Beta-10 proteinMonocyte Chemoattractant Protein 4 proteinMonocyte Chemotactic Protein 4 proteinMcp-4 proteinNcc-1 proteinSmall-Inducible Cytokine A13 Cleaved Into - C-C Motif Chemokine 13 - Long Chain - C-C Motif Chemokine 13 - Medium Chain - C-C Motif Chemokine 13 - Short Chain proteinCCL13 proteinMCP4 proteinNCC1 proteinSCYA13 protein |
Information sourced from Uniprot.org
